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Methods:Thre e hundred men were examined for signs and symptoms of
prostate dis orders.147patients with a digital rectal examination
indicating a positive result underwent a pros tate-s
pecificantigen(PSA)test.A biopsy was advised for 103 of the men,of whom
50 completed the s tudy.Be fore undergoing biopsy,an examination with
the EIS(e le ctro interstitial scan)system usingbioimpedance and
chronoamperometry was pe rfo rme d.In reference to the biopsy
results(negativeor positive),a statistical analysis of the EIS data and
PSA was conducted using receiver operatingcharacte ris tic curve s to de
te rmine the specificity and sensitivity of each test.
Res
ults:The PSA test had a sensitivity of 73.9%and specificity of
51.9%using a cutoff value>4and a sensitivity of 52.2%and
specificity of 81.5%using a cutoff value≥5.7 and P=0.03.The deltaof the
electrical conductivity(DE)of the left foot-right foot pathway had a
sensitivity of 62.5%andspecificity of 85.2%,with a cutoff value≤-5
andP=0.0001.Algorithms comprising the delta ofelectrical conductivity
and PSA showed a sensitivity of 91.5%and a specificity of 59.3%,with
acutoff value≤-10.52 andP=0.0003.
Conclusion:The EIS system had a
ve ry good specificity of 85.2%.Howe ve r,the sensitivity of 62.5%wo uld
be a pro ble m.Using a PSA reference.4.1 ng/mL,the adjunctive use of
bioimpedance and chronoamperometry provided by EIS technology could
raise the s e ns itivity from 73.9%to 91.5%and the specificity from
51.9%to 59.3%in prostate cancer screening.
結論：鷹演E.I.S系統(tǒng)具有很好的特異性為85.2%，通過EIS技術提供了生物電阻抗法的輔助使用，可在前列腺癌篩查中將特異性靈敏度從73.9%到91.5%和從51.9%到59.3%。
鷹演檢測在健康評估中的應用及價值
鷹演檢測測試有脂肪肝或者脂肪肝傾向的人群與腹部彩色多普勒超聲提示有輕度至重度脂肪肝人群比較，差異無統(tǒng)計學意義（P>0.05）,血糖血脂腫瘤標記物檢測比較，差異無統(tǒng)計意義
（P>0.05）。（1）鷹演檢測結果脂肪肝273例（58.5%）血糖升高290例（59.3%），無腫瘤風險360例（89.3%）。（2）腹部彩超結果脂肪肝227例（56.3%）。（3）血生化檢查血糖升高280例（69.5%）血脂升高230例（57.1%），符合空腹血糖>5.5mmol/L：總膽固醇，三酰甘油低脂肪膽固醇任意一項高于正常上限。（4）腫瘤標記物檢測各項均（-）無腫瘤風險358例（88.8%）。
?另外，在以上403例中，共有147符合代謝綜合征診斷標準（2001年，美國“國家膽固醇教育計劃”成年人治療組3次報告中提出工作定義），且行生物能清肝排毒和強化生活方式管理，3個月后復查鷹演檢測及腹部彩超多普勒超聲，血糖，血脂，腹部彩超多普勒超聲顯示脂肪肝程度減輕患者鷹演檢測均顯示肝臟功能好轉，血生化檢查提示血糖血脂下降患者，復查鷹演檢測提示干湯圓生成減少胰島功能改善血脂下降對比符合率100%。?結論：鷹演E.I.S在腫瘤檢測的篩查中，檢出無腫瘤風險360例（89.3%）對比常規(guī)腫瘤標記物檢出無腫瘤風險358例（88.8%），一致性達到99.4%以上，且陰性檢出率更高。
文獻出處：張于東，《中華保健醫(yī)學雜志》，2013全軍保健醫(yī)學學術研討會中國科技核心期刊，國家科技統(tǒng)計源期刊
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