大教堂由五座哥特式殿堂組成，包括王室座堂、主禮拜堂、大教堂博物館 等，殿堂之間以交叉的寬廣的回廊相連。

        主禮拜堂由橢圓形的穹頂覆蓋，內(nèi)部是火焰狀的翼部拱頂，形成高大的內(nèi)部空間。墻上掛著穆里略畫的各種著名宗教油畫。主禮拜堂是宗教活動(dòng)的主要場(chǎng)所，裝飾極為華麗，哥特式德祭壇薈萃了大量神態(tài)各異，栩栩如生的人物藝術(shù)雕像或繪畫，具有很高的鑒賞價(jià)值。與其他教堂不同的是，這里多少圣父抱著圣嬰，不是由圣母來抱，不知道是什么緣故。巨型祭壇浮雕描繪著基督生平的36個(gè)場(chǎng)景，裝飾極為華麗。禮拜堂柵欄為雕刻繁復(fù)的銀匠式風(fēng)格，以精美的花葉形作為裝飾。主禮拜堂的窗戶則是文藝復(fù)興風(fēng)格的鐵格窗。唱詩(shī)班的座席是穆德哈爾風(fēng)格，而管風(fēng)琴則為巴洛克風(fēng)格。

        教堂內(nèi)的王室座堂是西班牙文藝復(fù)興時(shí)期的早期作品，建筑物簡(jiǎn)潔的幾何造型結(jié)構(gòu)及其拱形圓頂?shù)谋砻娑疾紳M了富麗堂皇的復(fù)雜紋樣裝飾。在祭壇正中安放了一座代表塞維利亞地方保護(hù)神國(guó)王圣母的木刻雕像。雕像前有三個(gè)王室成員的骨灰盒。中間一個(gè)華貴的銀制骨灰盒是費(fèi)爾南多三世（1217～1252年在位）國(guó)王的遺骨，兩旁兩個(gè)分別是皇后和兒子阿方索十世(1252～1284年在位)的骨灰盒。

        塞維利亞大教堂盡管是歐洲的第三大教堂，但它更引人矚目的存放著哥倫布的骸骨。哥倫布于1451年出生在意大利，在港口城市熱那亞他接觸到了來自歐洲各地的船員，并有幸聽這些船員們講了一些出海的趣聞?shì)W事，從而使他對(duì)出海遠(yuǎn)航充滿無限向往。1479年，他與一位航海家的女兒結(jié)婚，有幸獲得了非常有價(jià)值的文件、日記和圖表。三年后，他成為一名船長(zhǎng)，開始了遠(yuǎn)洋探險(xiǎn)活動(dòng)?！恶R可.波羅游記》一書發(fā)表后，讓哥倫布產(chǎn)生了橫渡大西洋的想法。而他與當(dāng)時(shí)佛羅倫薩天文學(xué)家托斯堪內(nèi)利的書信往來使他知道了“地球是一個(gè)圓形的球體”。于是，他設(shè)想：如果從葡萄牙出發(fā)，向西直行，就一定能夠到達(dá)富庶的東方。1484年，哥倫布正式向葡萄牙國(guó)王若奧二世提出了到東方探險(xiǎn)的建議。這位國(guó)王當(dāng)場(chǎng)拒絕了此建議。被激怒的哥倫布把目光轉(zhuǎn)向了西班牙，1492年4月17日，具有遠(yuǎn)見卓識(shí)的伊莎貝拉此時(shí)力排眾議，與哥倫布簽訂了具有決定意義的《圣大非協(xié)定》：承認(rèn)哥倫布為新發(fā)現(xiàn)領(lǐng)土的海軍司令或總督；承認(rèn)西班牙君主為新發(fā)現(xiàn)領(lǐng)地的宗主和統(tǒng)治者；對(duì)于哥倫布獲得的金銀珠寶等享有免稅待遇；對(duì)于通過領(lǐng)地進(jìn)行貿(mào)易的船只，哥倫布享有部分股權(quán)。1492年8月至1493年3月，哥倫布開始了第一次探索橫渡大西洋的遠(yuǎn)洋航行：此行他首先發(fā)現(xiàn)了中南美洲的巴哈馬群島中的華特林島；接著繼續(xù)向西南航行，發(fā)現(xiàn)了加勒比海中的一些島嶼；在海地島，他下令用玻璃制品交換了“印第安人”的黃金。哥倫布這次偉大的發(fā)現(xiàn)，在人類探險(xiǎn)史中具有里程碑式的意義：雖然沒能發(fā)現(xiàn)他魂?duì)繅?mèng)繞的印度，但打通了通向大西洋的航路。 此航成功讓西班牙政府看到了開辟海外貿(mào)易的好處，費(fèi)爾南多與伊莎貝拉決定：在塞維利亞設(shè)立“印度群島（即美洲）交易之家”來統(tǒng)管西班牙海外貿(mào)易。這個(gè)機(jī)構(gòu)的設(shè)置極大地促進(jìn)了塞維利亞經(jīng)濟(jì)的發(fā)展，塞維利亞大教堂又繼續(xù)得以改建。1493年的當(dāng)年，哥倫布被任命為新發(fā)現(xiàn)陸地的總司令兼總督并再次遠(yuǎn)征，從歐洲航駛美洲加勒比海。首先發(fā)現(xiàn)了南美大陸和中美地峽；發(fā)現(xiàn)了大安的列斯群島的古巴、海地、牙買加和波多黎各；發(fā)現(xiàn)了巴哈馬群島和小安的列斯群島的大部分島嶼，同時(shí)他還發(fā)現(xiàn)了特立尼達(dá)島和加勒比海一系列較小的島嶼。1497年，哥倫布奉命開始第三次遠(yuǎn)航。遺憾的是哥倫布此行依然未跳出固有思維的束縛，還是在南美洲范疇“打轉(zhuǎn)轉(zhuǎn)”，無有新獲。然而，1499年8月，葡萄牙航海家達(dá).珈馬率領(lǐng)船隊(duì)從印度返回里斯本，不僅開通了亞洲新航線，且?guī)Щ亓藲W洲人夢(mèng)寐以求的香料、絲綢、寶石、象牙等。于是有人開始誣陷哥倫布侵吞王室財(cái)產(chǎn)并虐殺土著人，等等。于是他被撤銷職務(wù)，王室也中止了《圣大非協(xié)定》。1502年，50歲高齡的哥倫布癡心不改，懇求王室允許他再次遠(yuǎn)航。5月9日，哥倫布率領(lǐng)由4艘船和150名船員組成的探險(xiǎn)隊(duì)，開始了他第四次也是最后一次探險(xiǎn)遠(yuǎn)航。船隊(duì)到達(dá)加勒比海后，開始尋找馬六甲海峽，但無結(jié)果。1504年11月7日，哥倫布結(jié)束在外歷時(shí)兩年半的最后航行駛進(jìn)瓜達(dá)爾基維爾河河口時(shí)，雖身患重病，情緒憂郁，得到的也只是國(guó)王的一道命令：變賣哥倫布全部動(dòng)產(chǎn)，查封其他財(cái)產(chǎn)，以便清算他的債務(wù)。1506年5月20日這位偉大的航海家與世長(zhǎng)辭時(shí)，身邊沒有任何人照料，遺體被安葬于塞維利亞大教堂。

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